Nicolas Le Sueur was born in 1691 in Paris. He came from a French wood-engraver family and is its most famous member. He was the son of Pierre Le Sueur (1663–98) and probably the father of Blaise Nicolas Le Sueur (1716–83). The artist signed his works with the initials "NLS".
He especially cultivated the light-dark cut (chiaroscuro cut) with the connection of line etchings and clay plates. Nicolas Le Sueur also made the 30 sheets for the Cabinet Crozat (1729-42) using this technique. In addition, he also made vignettes and book illustrations.
Nicolas Le Sueur died in 1764 in Paris.